INTRODUCTION: The role of botulinum toxin as a therapeutic agent for several conditions is
expanding. We sought to determine if botulinum toxin is safe and effective in treating
patients with cervical dystonia and maxillofacial conditions. Our purpose was to establish a
safety and efficacy profile to determine whether or not this treatment may be used
prophylactically in patients undergoing dental implant therapy. METHODS: We performed a
systematic search of the literature to identify randomized clinical trials evaluating patients …

Results No RCT were identified that evaluated dental implant therapy along with use of BTX.
Four RCT did meet the search criteria in the area of cervical dystonia and chronic facial pain.
People who had cervical dystonia exhibited significant improvements in baseline functional,
pain and global assessments compared with placebo, whereas individuals with chronic
facial pain improved significantly compared with placebo in terms of pain. Conclusions
During the period of study, no references were found evaluating use of BTX in dental …